Mixed lineage leukaemia histone methylases 1 collaborate with ERα to regulate HOXA10 expression in AML
نویسندگان
چکیده
منابع مشابه
Mixed lineage leukaemia histone methylases 1 collaborate with ERα to regulate HOXA10 expression in AML
HOXA10, a homeobox-containing gene involved in definitive haematopoiesis, which implicated in the pathogenesis of AML (acute myeloid leukaemia), has been studied extensively. But the regulatory mechanism that drives HOXA10 expression is still unclear. In the present paper, HOXA10 regulated by MLL1 (mixed lineage leukaemia histone methylase 1) with an epigenetic way has been demonstrated. The HO...
متن کاملThe lineage-defining factors T-bet and Bcl-6 collaborate to regulate Th1 gene expression patterns
The T-box transcription factor T-bet is important for the differentiation of naive CD4(+) T helper cells (Th cells) into the Th1 phenotype. Much is known about T-bet's role as a transcriptional activator, but less is known about the mechanisms by which T-bet functionally represses alternative Th cell genetic programs. In this study, we first identify Socs1, Socs3, and Tcf7 (TCF-1) as gene targe...
متن کاملAML 1 / RUNX 1 DNA binding sequences to differentially regulate
Chromosome abnormalities are frequently associated with cancer development. The 8;21(q22;q22) chromosomal translocation is one of the most common chromosome abnormalities identified in leukemia. It generates fusion proteins between AML1 and ETO. Since AML1 is a well defined DNA binding protein, AML1-ETO fusion proteins have been recognized as DNA binding proteins interacting with the same conse...
متن کاملPhotoperiod Influences Growth and mll (Mixed-Lineage Leukaemia) Expression in Atlantic Cod
Photoperiod is associated to phenotypic plasticity of somatic growth in several teleost species. However, the molecular mechanisms underlying this phenomenon are currently unknown but it is likely that epigenetic regulation by methyltransferases is involved. The MLL (mixed-lineage leukaemia) family comprises histone methyltransferases that play a critical role in regulating gene expression duri...
متن کاملMixed Lineage Kinase Domain-Like Pseudokinase (MLKL) Gene Expression in Human Atherosclerosis with and without Type 2 Diabetes Mellitus
Background: MLKL, one of the main downstream components of the necroptosis or programmed necrosis has recently been demonstrated in advanced atherosclerotic lesions. However, its precise role in the atherosclerosis pathogenesis still requires more elucidation. Our study was set to delineate both the changes in peripheral MLKL gene expression and its influence on disease severity in atherosclero...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Bioscience Reports
سال: 2014
ISSN: 0144-8463,1573-4935
DOI: 10.1042/bsr20140116